| Place of Origin: | Anhui China |
|---|---|
| Brand Name: | AJA |
| Minimum Order Quantity: | 1KG |
| Price: | USD10-20/kg |
| Packaging Details: | 25KG/drum |
| CAS NO: | 23593-75-1 | EINEC NO: | 245-764-8 |
|---|---|---|---|
| MF: | C22H17ClN2 | MW: | 344.84 |
| Apperance: | White Crystalline Powder | Usage: | API |
| Package: | 25kg/drum | Purity: | 99% |
| Highlight: | 23593-75-1 API And Intermediates,USP36 API And Intermediates,clotrimazole antifungal powder |
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API Pharmaceutical Intermeidates White Crystal Powder Clotrimazole
Product Name: Clotrimazole
Standard: USP31/BP2007/CP2005
CAS No:23593-75-1
Molecular Formula: C22H17ClN2
Molecular Weight: 344.84
Introduction:
Clotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.
Medical uses
It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops. Fungal infections can be slow to clear up, so the usual course for an anti-fungal agent is, in general, longer than the typical 3–7 days of an antibiotic. Clotrimazole is also commonly found in conjunction with Betamethasone, known as Lotriderm, Additionally, Clotrimazole is used to treat the sickling of cells (related to sickle cell anemia) by blocking ion channels in the RBC (red blood cell) membrane, keeping ions and water within the cell.
Main Function;
1. Clotrimazole is an anti-fungal medication commonly used in the treatment of fungal infections of both humans and
other animals suchas vaginal yeast infections. oral thrush, and ringworm.
2. It is also used to treat athlets's foot and jock itch.
Certificate of Analysis:
| Specification | Standard | Result |
| Characters | White to pale yellow crystalline powder | A white crystallin powder |
|
Identification: A. Infrared absoption
B. TLC Idetification TEST |
The IRspectrum of sample, exhibits maxima only at the same wavelength as that a similar preparation of USPClotrimazole RS.
The RF value of the principal spot obtained from the test solution corresponds to that obtained from the Standar solution. |
Complies. |
| Melting Point | 141 to 145°C | 142.5 to 143.5°C |
| Loss on drying | Not more than 0.5% | 0.2% |
| Residue on ignition | Not more than 0.1% | 0.05% |
| Heavy metals | Not more than 0.001% | Complies. |
| Limit of imidazole | Not more than 0.5% | 0.21% |
| Limit of clotrimazole related compound A | Not more than 0.5% | 0.1% |
| Assay(on the dried basis) | Not less than 98% and not more than 102% | 99.8% |
| CONCLUSION | UP TO USP36 STANDARD |
